At a glance
- Mechanism of action
- Regenerative peptide derived from a protective protein in gastric juice: triggers angiogenesis (new blood vessels) in injured tissue and thereby improves supply to poorly perfused tendons and ligaments.
- Benefits & use
- Said to speed healing of tendons, ligaments, muscle and gut (e.g. leaky gut, IBS); popular in strength and combat sports.
- Study status
- Level 1-2: Three small, open, non-placebo-controlled human pilot studies (intra-articular for knee pain 2021; intravesical for interstitial cystitis 2024; i.v. safety in 2 subjects 2025) show no serious short-term adverse effects, but no controlled endpoints. A narrative review (McGuire et al., 2025) continues to describe the human evidence as "sparse and fraught with methodological weaknesses"; a sports medicine review (Vasireddi et al., 2025) confirms the same picture with no clinical human safety data. Active: randomized Phase-2 trial in acute hamstring injury (NCT07437547). WADA: still listed under S0 (Prohibited List 2026 in force).
- Dosing note
- Vials 5-10 mg; subcutaneous locally at the injury or oral (gut). No dosing instructions - information only.
Use in the injection calculator
BPC-157 (Body Protection Compound) is a regenerative peptide derived from a protective protein in gastric juice. It promotes the formation of new blood vessels (angiogenesis) and can thereby speed the healing of poorly perfused tendons and ligaments. Evidence: level 1-2.
How does BPC-157 work?
In the stomach, the source protein constantly repairs micro-injuries. Injected into injured tissue, BPC-157 triggers angiogenesis: new blood vessels grow into the area. Because tendons and ligaments are barely perfused (and therefore heal slowly), better blood supply can speed healing considerably. The mechanism is regenerative and local, not systemic like the GLP-1 weight-loss drugs.
What is BPC-157 used for?
In strength and combat sports and in biohacking it is treated as a "cure" for tendinitis, tennis elbow, ligament and muscle injuries, and after surgery. Taken orally, it is used for gut healing (leaky gut, IBS, ulcers). People often pair it conceptually with regeneration stacks such as CJC-1295 / Ipamorelin. Want to log what you try? Create a free account.
What does the evidence say?
There is a large gap: many anecdotal successes, but almost only animal studies (rats, pigs). A body-derived protein is hard to patent, so there is little incentive for expensive approval trials. Important: the WADA has banned BPC-157 for athletes since 2022. For volume and reconstitution questions, see the injection calculator and the FAQ.
Note: Educational information, not medical advice. Many of these substances are experimental and not approved for human use.
Related peptides
Sources
- McGuire et al. 2025: Regeneration or Risk? Narrative Review of BPC-157 (Curr Rev Musculoskelet Med) - PubMed
- Lee et al. 2024: BPC-157 in Interstitial Cystitis (Altern Ther Health Med) - PubMed
- McGuire et al. 2025 - PMC full text
- Vasireddi et al. 2025: Emerging Use of BPC-157 in Orthopaedic Sports Medicine - PubMed
- Hudson Biotech: Phase-2 RCT of BPC-157 in acute hamstring injury (NCT07437547) - ClinicalTrials.gov
- WADA 2026 Prohibited List (in force since 1 January 2026) - PDF
- USADA: BPC-157 peptide prohibited